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叶绿体基因组 1

对比分析 1

鼠尾草属 1

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Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

《医学前沿（英文）》 2010年 第4卷 第3期   页码 317-322 doi: 10.1007/s11684-010-0035-4

摘要： The inhibitory effect of different reperfusion periods 45 min following hepatic ischemia on the expression of cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in the jejunum and the effect of salvia miltiorrhiza pretreatment were investigated, and the possible mechanism and implications were explored. Eighty rats were randomly divided into four groups: normal control group (CO group), sham-operated group (SO group), ischemia/reperfusion (I/R) injury group (IR group) and salvia miltiorrhiza pretreatment group (SM group). The rat model of I/R was established by using a non-invasive artery clamp to clip (45 min) or relax the hepatic pedicle. In the SM group, saline (40 mL/kg) and salvia miltiorrhiza injection (6 g/kg) were injected via the tail vein 30 min before clipping the hepatic pedicle. In the SO group only the porta hepatis was dissected after laparotomy without clamping the hepatic pedicle. At 0, 3, 12, 24 and 72 h post-reperfusion, respectively, upper jejunum samples were taken for immunohistochemistry of CCK and VIP. It was found that 0 h after I/R, the expression of CCK and VIP in the upper jejunum was upregulated. With prolongation of the reperfusion period, the expression of CCK and VIP was also increased, reached the peak at the 24th h, and gradually returned to the normal level at the 72nd h after reperfusion. The levels of both CCK and VIP in the SM group were lower than those in the IR group. It is suggested that the digestive tract congestion injury caused by liver ischemia can upregulate the expression of CCK and VIP in the jejunum following reperfusion. Salviae pretreatment can partly reduce the increased expression of CCK and VIP in the jejunum in the same period, which might contribute to the early recovery of gastrointestinal motility.

关键词： hepatic ischemia-reperfusion     digestive tract congestion     cholecystokinin     vasoactive intestinal peptide     salvia miltiorrhiza    

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4种鼠尾草药用植物叶绿体基因组的对比分析 Article

梁从莲, 王磊, 雷隽, 段宝忠, 马维思, 肖水明, 齐海军, 王振, 刘尧奇, 沈晓凤, 郭帅, 胡灏禹, 徐江, 陈士林

《工程（英文）》 2019年 第5卷 第5期   页码 907-915 doi: 10.1016/j.eng.2019.01.017

摘要： 鼠尾草属（Salvia. Linn.）是唇形科的一个大属，包括很多重要的药用植物。（S. bulleyana）——的叶绿体（cp）全基因组进行了测序，并与另外两种已有叶绿体全基因组公布的鼠尾草——丹参（S. miltiorrhiza

关键词： 鼠尾草属     叶绿体基因组     对比分析    

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标题 作者 时间 类型 操作

Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

期刊论文

4种鼠尾草药用植物叶绿体基因组的对比分析

梁从莲, 王磊, 雷隽, 段宝忠, 马维思, 肖水明, 齐海军, 王振, 刘尧奇, 沈晓凤, 郭帅, 胡灏禹, 徐江, 陈士林

期刊论文